资源类型

期刊论文 469

会议信息 1

年份

2024 1

2023 25

2022 35

2021 41

2020 43

2019 44

2018 34

2017 45

2016 28

2015 34

2014 16

2013 21

2012 19

2011 10

2010 14

2009 18

2008 10

2007 11

2006 5

2005 1

展开 ︾

关键词

调节性T细胞 3

光催化 2

基因编辑 2

癌症 2

(美国) 核管理委员会 1

/III-V界面 1

1T/2H-MoS2 1

2020 1

2R-1C模型；嵌入式系统；参数估计；非迭代方法；二次型 1

3D打印 1

7815 1

9 %~12 % Cr 钢 1

&prime 1

&gamma 1

ANSYS 1

ATSC 1

BALB/C小鼠 1

BDS/GPS双系统定轨 1

BDS码偏差 1

展开 ︾

检索范围：

排序： 展示方式：

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

《医学前沿（英文）》 2007年 第1卷 第2期   页码 230-233 doi: 10.1007/s11684-007-0045-z

摘要： The relationship between the tenth exon C825T of G-protein β3 subunit (GNB) genetic polymorphism and hypertension in the Uygur population of China was investigated. A nested case-control study ( = 738) was carried out. Polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP) technique was used to genotype GNB C825T polymorphism in 354 hypertensive (HT) and 384 normotensive (NT) Uygur subjects. The distributions of GNB C825T genotypes were CC (27.2%), TT (42.9%), and CT (29.9%) in the hypertensive subjects and CC (27.7%), TT (42.4%), CT (29.9%) in the normotensive subjects. There were no significant differences in the genotype distributions between the two groups ( = 0.0262 P = 0.99). The T allele was 51.4% in hypertensive subjects and 51.2% in normotensive subjects, which, between the two groups, was not a significant difference ( = 0.0016 P = 0.97). Further analysis shows that there is no association between C825T genotypes and age, body mass index (BMI), Glucose (GLU), Triglyceride (TG), Cholesterol (CHO), systolic blood pressure (SBP) and diastolic blood pressure (DBP). No evidence was found to suggest an association between GNB C825T polymorphism and hypertension in the Uygur population of China.

关键词： case-control     significant difference     reaction-restriction fragment     C825T polymorphism     evidence    

HTML PDF 收藏

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

null

《医学前沿（英文）》 2013年 第7卷 第1期   页码 138-142 doi: 10.1007/s11684-013-0247-5

摘要：

It has been demonstrated that single nucleotide polymorphisms (SNPs) of SIPA1 (signal-induced proliferation associated gene 1) are associated with metastatic efficiency in both human and rodents. The purpose of this study was to determine whether SIPA1 545 C>T polymorphism was associated with overall survival in patients with metastatic breast cancer. In this study, SIPA1 545 C>T polymorphism was detected in 185 metastatic breast cancer patients using polymerase chain reaction-restriction fragment length polymorphism assay (PCR-RFLP). Survival curves for patients with SIPA1 545 C>T polymorphism was compared using the Kaplan-Meier method with log-rank tests. We found that SIPA1 545 C>T polymorphism was significantly associated with survival in 185 patients with metastatic breast cancer. Patients with SIPA1545 T/T genotype had a significantly worse overall survival (OS) than did patients with C/T or C/C genotype (50.0% vs. 62.9%, P = 0.042). Moreover, in multivariate analysis, as compared with the C/C or C/T genotype, the T/T genotype remained an independent unfavorable prognostic marker of OS in this cohort (hazard ratio [HR] = 2.16; 95% CI= 1.12–4.15; P = 0.022). Our findings indicate that metastatic breast cancer patients with SIPA1 545 T/T genotype have a poorer survival compared to patients with C/C or C/T genotype.

关键词： SIPA1     polymorphism     metastatic breast cancer     survival    

HTML PDF 收藏

Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

《结构与土木工程前沿（英文）》 2012年 第6卷 第1期   页码 1-18 doi: 10.1007/s11709-012-0141-2

摘要： This paper presents a comprehensive review of modeling of alkali-silica reaction (ASR) in concrete. Such modeling is essential for investigating the chemical expansion mechanism and the subsequent influence on the mechanical aspects of the material. The concept of ASR and the mechanism of expansion are first outlined, and the state-of-the-art of modeling for ASR, the focus of the paper, is then presented in detail. The modeling includes theoretical approaches, meso- and macroscopic models for ASR analysis. The theoretical approaches dealt with the chemical reaction mechanism and were used for predicting pessimum size of aggregate. Mesoscopic models have attempted to explain the mechanism of mechanical deterioration of ASR-affected concrete at material scale. The macroscopic models, chemo-mechanical coupling models, have been generally developed by combining the chemical reaction kinetics with linear or nonlinear mechanical constitutive, and were applied to reproduce and predict the long-term behavior of structures suffering from ASR. Finally, a conclusion and discussion of the modeling are given.

关键词： alkali-silica reaction (ASR)     modeling     concrete     mesoscopic     macroscopic    

HTML PDF 收藏

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

《医学前沿（英文）》 2022年 第16卷 第1期   页码 150-155 doi: 10.1007/s11684-021-0846-5

摘要： Cystic fibrosis (CF) is a rare autosomal recessive disease with only one pathogenic gene cystic fibrosis transmembrane conductance regulator (CFTR). To identify the potential pathogenic mutations in a Chinese patient with CF, we conducted Sanger sequencing on the genomic DNA of the patient and his parents and detected all 27 coding exons of CFTR and their flanking intronic regions. The patient is a compound heterozygote of c.2909G>A, p.Gly970Asp in exon 18 and c.1210-3C>G in cis with a poly-T of 5T (T5) sequence, 3 bp upstream in intron 9. The splicing effect of c.1210-3C>G was verified via minigene assay in vitro, indicating that wild-type plasmid containing c.1210-3C together with T7 sequence produced a normal transcript and partial exon 10-skipping-transcript, whereas mutant plasmid containing c.1210-3G in cis with T5 sequence caused almost all mRNA to skip exon 10. Overall, c.1210-3C>G, the newly identified pathogenic mutation in our patient, in combination with T5 sequence in cis, affects the CFTR gene splicing and produces nearly no normal transcript in vitro. Moreover, this patient carries a p.Gly970Asp mutation, thus confirming the high-frequency of this mutation in Chinese patients with CF.

关键词： cystic fibrosis     CFTR     splicing mutation     minigene    

HTML PDF 收藏

Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis

Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN

《环境科学与工程前沿（英文）》 2009年 第3卷 第2期   页码 194-199 doi: 10.1007/s11783-009-0018-3

摘要： Four typical coastal sites (rocky shore, sandy shore, mud flat shore, and artificial harbor) at the Yellow Sea were chosen to investigate the spatial and seasonal variations in bacterial communities. This was accomplished by using terminal restriction fragment length polymorphism (T-RFLP) analysis of PCR amplified 16S rDNA fragments. Two kinds of tetrameric restriction enzymes, I and I, were used in the experiment to depict the bacterial community diversity in different marine environments. It was found that the community compositions digested by the two enzymes separately were different. However, the results of bacterial community diversity derived from them were similar. The MDA analysis results of T-RFLP profiles coming from I and I both exhibited a significant seasonal community shift for bacteria and a relatively low spatial variation among the four locations. With I as the sample, the pair wise -tests also revealed that variations were minor between each pair of marine environments, with ranging from 0.198 to 0.349. However, the bacterial community structure in the mud flat site depicted a larger difference than each of the other three sites ( ranging from 0.282 to 0.349).

关键词： terminal restriction fragment length polymorphism (T-RFLP)     bacterial community structure     marine microbial diversity     HhaI     MspI    

HTML PDF 收藏

Current molecular biologic techniques for characterizing environmental microbial community

Dawen GAO, Yu TAO

《环境科学与工程前沿（英文）》 2012年 第6卷 第1期   页码 82-97 doi: 10.1007/s11783-011-0306-6

摘要： Microbes are vital to the earth because of their enormous numbers and instinct function maintaining the natural balance. Since the microbiology was applied in environmental science and engineering more than a century ago, researchers desire for more and more information concerning the microbial spatio-temporal variations in almost every fields from contaminated soil to wastewater treatment plant (WWTP). For the past 30 years, molecular biologic techniques explored for environmental microbial community (EMC) have spanned a broad range of approaches to facilitate the researches with the assistance of computer science: faster, more accurate and more sensitive. In this feature article, we outlined several current and emerging molecular biologic techniques applied in detection of EMC, and presented and assessed in detail the application of three promising tools.

关键词： molecular biological technique     microbial community     denaturing gradient gel electrophoresis (DGGE)     terminal restriction fragment length polymorphism (T-RFLP)     environmental applications    

HTML PDF 收藏

Shear design of high strength concrete prestressed girders

DHONDE,Thomas T. C. HSU,Y. L. MO

《结构与土木工程前沿（英文）》 2014年 第8卷 第4期   页码 373-387 doi: 10.1007/s11709-014-0087-7

摘要： Normal strength prestressed concrete I-girders are commonly used as the primary superstructure components in highway bridges. However, shear design guidelines for high strength PC girders are not available in the current structural codes. Recently, ten 7.62 m (25 feet) long girders made with high strength concrete were designed, cast, and tested at the University of Houston (UH) to study the ultimate shear strength and the shear concrete contribution ( ) as a function of concrete strength ( ). A simple semi-empirical set of equations was developed based on the test results to predict the ultimate shear strength of prestressed concrete I-girders. The UH-developed set of equations is a function of concrete strength ( ), web area ( ), shear span to effective depth ratio ( / ), and percentage of transverse steel ( ). The proposed UH-Method was found to accurately predict the ultimate shear strength of PC girders with concrete strength up to 117 MPa (17000 psi) ensuring satisfactory ductility. The UH-Method was found to be not as overly conservative as the ACI-318 (2011) code provisions, and also not to overestimate the ultimate shear strength of high strength PC girders as the AASHTO LRFD (2010) code provisions. Moreover, the proposed UH-Method was found fairly accurate and not exceedingly conservative in predicting the concrete contribution to shear for concrete strength up to 117 MPa (17000 psi).

关键词： shear design     high strength concrete     prestressed girders     full-scale tests    

HTML PDF 收藏

Thermal degradation characteristics and products obtained after pyrolysis of specific polymers found in Waste Electrical and Electronic Equipment

Evangelia C. Vouvoudi, Aristea T. Rousi, Dimitris S. Achilias

《环境科学与工程前沿（英文）》 2017年 第11卷 第5期 doi: 10.1007/s11783-017-0996-5

摘要： Modern societies strongly support the recycling practices over simple waste accumulation due to environmental harm caused. In the framework of sustainable recycling of plastics from WEEE, pyrolysis is proposed here as a means of obtaining secondary value-added products. The aim of this study was to investigate the thermal degradation and the products obtained after pyrolysis of specific polymers found in the plastic part of WEEE, using thermogravimetric analysis and a pyrolizer equipped with a GC/MS. Polymers studied include ABS, HIPS, PC and a blend having a composition similar to that appearing in WEEE. It was found that, PC shows greater heat endurance compared to the other polymers, whereas ABS depolymerizes in three-steps. The existence of several polymers in the blend results in synergistic effects which decrease the onset and final temperature of degradation. Moreover, the fragmentation occurred in the pyrolyzer, at certain temperatures, resulted in a great variety of compounds, depending on the polymer type, such as monomers, aromatic products, phenolic compounds and hydrocarbons. The main conclusion from this investigation is that pyrolysis could be an effective method for the sustainable recycling of the plastic part of WEEE resulting in a mixture of chemicals with varying composition but being excellent to be used as fuel retrieved from secondary recycling sources.

关键词： Pyrolysis     WEEE recycling     ABS     HIPS     PC     Py-GC/MS     TGA    

HTML PDF 收藏

Thermal-aware relocation of servers in green data centers

Muhammad Tayyab CHAUDHRY,T. C. LING,S. A. HUSSAIN,Xin-zhu LU

《信息与电子工程前沿（英文）》 2015年 第16卷 第2期   页码 119-134 doi: 10.1631/FITEE.1400174

摘要： Rise in inlet air temperature increases the corresponding outlet air temperature from the server. As an added effect of rise in inlet air temperature, some active servers may start exhaling intensely hot air to form a hotspot. Increase in hot air temperature and occasional hotspots are an added burden on the cooling mechanism and result in energy wastage in data centers. The increase in inlet air temperature may also result in failure of server hardware. Identifying and comparing the thermal sensitivity to inlet air temperature for various servers helps in the thermal-aware arrangement and location switching of servers to minimize the cooling energy wastage. The peak outlet temperature among the relocated servers can be lowered and even be homogenized to reduce the cooling load and chances of hotspots. Based upon mutual comparison of inlet temperature sensitivity of heterogeneous servers, this paper presents a proactive approach for thermal-aware relocation of data center servers. The experimental results show that each relocation operation has a cooling energy saving of as much as 2.1 kW·h and lowers the chances of hotspots by over 77%. Thus, the thermal-aware relocation of servers helps in the establishment of green data centers.

关键词： Servers     Green data center     Thermal-aware     Relocation    

HTML PDF 收藏

A multi-scale model for CO

RUDOLPH, C. T. WEI, Y. QIN

《化学科学与工程前沿（英文）》 2009年 第3卷 第1期   页码 20-25 doi: 10.1007/s11705-009-0138-0

摘要： This paper presents a multi-scale model to simulate the multicomponent gas diffusion and flow in bulk coals for CO sequestration enhanced coalbed methane recovery. The model is developed based on a bi-dispersed structure model by assuming that coal consists of microporous micro-particles, meso/macro-pores and open microfractures. The bi-disperse diffusion theory and the Maxwell-Stefan approach were incorporated in the model, providing an improved simulation of the CH —CO /CH —N counter diffusion dynamics. In the model, the counter diffusion process is numerically coupled with the flow of the mixture gases occurring within macro-pores or fractures in coal so as to account for the interaction between diffusion and flow in gas transport through coals. The model was validated by both experimental data from literature and our CO flush tests, and shows an excellent agreement with the experiments. The results reveal that the gas diffusivities, in particular the micro-pore diffusivities are strongly concentration-dependent.

关键词： multi-scale model     gas transport     coal     coalbed methane     CO2 sequestration    

HTML PDF 收藏

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

《医学前沿（英文）》 2019年 第13卷 第3期   页码 388-397 doi: 10.1007/s11684-018-0624-1

摘要： Collaboration of c-KIT mutations with AML1–ETO (AE) has been demonstrated to induce t(8; 21) acute myeloid leukemia (AML). Targeted therapies designed to eliminate AE and c-KIT oncoproteins may facilitate effective treatment of t(8; 21) AML. Homoharringtonine (HHT) features activity against tumor cells harboring c-KIT mutations, whereas oridonin can induce t(8; 21) AML cell apoptosis and AE cleavage. Therefore, studies should explore the efficacy of combination therapy with oridonin and HHT in t(8; 21) AML. In this study, we investigated the synergistic effects and mechanism of oridonin combined with HHT in t(8; 21) AML cell line and mouse model. The two drugs synergistically inhibited cell viability and induced significant mitochondrial membrane potential loss and apoptosis. Oridonin and HHT induced significant downregulation of c-KIT and its downstream signaling pathways and promoted AE cleavage. HHT increased intracellular oridonin concentration by modulating the expressions of MRP1 and MDR1, thus enhancing the effects of oridonin. The combination of oridonin and HHT prolonged t(8; 21) leukemia mouse survival. In conclusion, oridonin and HHT exert synergistic effects against t(8; 21) leukemia and , thereby indicating that their combination may be an effective therapy for t(8; 21) leukemia.

关键词： AML1–ETO     c-KIT     homoharringtonine     oridonin     t(8     21) AML     synergistic effect    

HTML PDF 收藏

Using a systems modeling approach to improve soil management and soil quality

SMITH, Ben C. T. MACDONALD

《农业科学与工程前沿（英文）》 2020年 第7卷 第3期   页码 289-295 doi: 10.15302/J-FASE-2020337

摘要：

Soils provide the structural support, water and nutrients for plants in nature and are considered to be the foundation of agriculture production. Improving soil quality and soil health has been advocated as the goal of soil management toward sustainable agricultural intensification. There have been renewed efforts to define and quantify soil quality and soil health but establishing a consensus on the key indicators remains difficult. It is argued that such difficulties are due to the former ways of thinking in soil management which largely focus on soil properties alone. A systems approach that treats soils as a key component of agricultural production systems is promoted. It is argued that soil quality must be quantified in terms of crop productivity and impacts on ecosystems services that are also strongly driven by climate and management interventions. A systems modeling approach captures the interactions among climate, soil, crops and management, and their impacts on system performance, thus helping to quantify the value and quality of soils. Here, three examples are presented to demonstrate this. In this systems context, soil management must be an integral part of systems management practices that also include managing the crops and cropping systems under specific climatic conditions, with cognizance of future climate change.

关键词： APSIM     available water capacity     nitrogen management     soil functional properties     soil health     soil-plant modeling    

HTML PDF 收藏

Design of active orthoses for a robotic gait rehabilitation system

C. VILLA-PARRA,L. BROCHE,D. DELISLE-RODRÍGUEZ,R. SAGARÓ,T. BASTOS,A. FRIZERA-NETO

《机械工程前沿（英文）》 2015年 第10卷 第3期   页码 242-254 doi: 10.1007/s11465-015-0350-1

摘要：

An active orthosis (AO) is a robotic device that assists both human gait and rehabilitation therapy. This work proposes portable AOs, one for the knee joint and another for the ankle joint. Both AOs will be used to complete a robotic system that improves gait rehabilitation. The requirements for actuator selection, the biomechanical considerations during the AO design, the finite element method, and a control approach based on electroencephalographic and surface electromyographic signals are reviewed. This work contributes to the design of AOs for users with foot drop and knee flexion impairment. However, the potential of the proposed AOs to be part of a robotic gait rehabilitation system that improves the quality of life of stroke survivors requires further investigation.

关键词： active orthosis     gait rehabilitation     electroencephalography     surface electromyography    

HTML PDF 收藏

Towards Cr(VI)-free anodization of aluminum alloys for aerospace adhesive bonding applications: A review

Shoshan T. Abrahami, John M. M. de Kok, Herman Terryn, Johannes M. C. Mol

《化学科学与工程前沿（英文）》 2017年 第11卷 第3期   页码 465-482 doi: 10.1007/s11705-017-1641-3

摘要： For more than six decades, chromic acid anodizing (CAA) has been the central process in the surface pre-treatment of aluminum for adhesively bonded aircraft structures. Unfortunately, this electrolyte contains hexavalent chromium (Cr(VI)), a compound known for its toxicity and carcinogenic properties. To comply with the new strict international regulations, the Cr(VI)-era will soon have to come to an end. Anodizing aluminum in acid electrolytes produces a self-ordered porous oxide layer. Although different acids can be used to create this type of structure, the excellent adhesion and corrosion resistance that is currently achieved by the complete Cr(VI)-based process is not easily matched. This paper provides a critical overview and appraisal of proposed alternatives to CAA, including combinations of multiple anodizing steps, pre- and post anodizing treatments. The work is presented in terms of the modifications to the oxide properties, such as morphological features (e.g., pore size, barrier layer thickness) and surface chemistry, in order to evaluate the link between fundamental principles of adhesion and bond performance.

关键词： aluminum     Cr(VI)-free     surface pre-treatments     anodizing     adhesive bonding    

HTML PDF 收藏

Community dynamics of ammonia oxidizing bacteria in a full-scale wastewater treatment system with nitrification stability

Xiaohui WANG, Xianghua WEN, Hengjing YAN, Kun DING, Man HU

《环境科学与工程前沿（英文）》 2011年 第5卷 第1期   页码 92-98 doi: 10.1007/s11783-010-0254-6

摘要： To determine whether the functional stability of nitrification was correlated to a stable community structure of ammonia oxidizing bacteria (AOB) in a full-scale wastewater treatment plant, the AOB community dynamics in a wastewater treatment system was monitored over one year. The community dynamics were investigated using specific PCR followed by terminal restriction fragment length polymorphism (T-RFLP) analysis of the gene. The T-RFLP results indicated that during the period of nitrification stability, the AOB community structure in the full-scale wastewater treatment system was relatively stable, and the average change rate every 15 d of the system was 6.6%±5.8%. The phylogenetic analysis of the cloned gene showed clearly that the dominant AOB in the system was spp. The results of this study indicated that throughout the study period, the AOB community structure was relatively stable in the full-scale wastewater treatment system with functional stability of nitrification.

关键词： ammonia-oxidizing bacteria (AOB)     community dynamics     terminal restriction fragment length polymorphism (T-RFLP)     nitrification performance    

HTML PDF 收藏

标题 作者 时间 类型 操作

Association study on GNB3 gene polymorphism with essential hypertension in Xinjiang Uygur group

JING Jianying, WANG Dan, WANG Xiaofeng, JIN Jianzhong, JIN Li, JIAO Yi, WEN Hao, LIN Renyong

期刊论文

Association of SIPA1 545 C>T polymorphism with survival in Chinese women with metastatic breast cancer

null

期刊论文

Modeling of alkali-silica reaction in concrete: a review

PAN, Y.T. FENG, J.T. WANG, Q.C. SUN, C.H. ZHANG, D.R.J. OWEN

期刊论文

Novel mutation c.1210-3C>G in with a poly-T tract of 5T affects mRNA splicing in a Chinese patient

期刊论文

Spatial and seasonal variations in bacterial communities of the Yellow Sea by T-RFLP analysis

Hongyuan WANG, Xiaolu JIANG, Ya HE, Huashi GUAN

期刊论文

Current molecular biologic techniques for characterizing environmental microbial community

Dawen GAO, Yu TAO

期刊论文

Shear design of high strength concrete prestressed girders

DHONDE,Thomas T. C. HSU,Y. L. MO

期刊论文

Thermal degradation characteristics and products obtained after pyrolysis of specific polymers found in Waste Electrical and Electronic Equipment

Evangelia C. Vouvoudi, Aristea T. Rousi, Dimitris S. Achilias

期刊论文

Thermal-aware relocation of servers in green data centers

Muhammad Tayyab CHAUDHRY,T. C. LING,S. A. HUSSAIN,Xin-zhu LU

期刊论文

A multi-scale model for CO

RUDOLPH, C. T. WEI, Y. QIN

期刊论文

Homoharringtonine synergy with oridonin in treatment of t(8; 21) acute myeloid leukemia

Weina Zhang, Ying Lu, Tao Zhen, Xinjie Chen, Ming Zhang, Ping Liu, Xiangqin Weng, Bing Chen, Yueying Wang

期刊论文

Using a systems modeling approach to improve soil management and soil quality

SMITH, Ben C. T. MACDONALD

期刊论文

Design of active orthoses for a robotic gait rehabilitation system

C. VILLA-PARRA,L. BROCHE,D. DELISLE-RODRÍGUEZ,R. SAGARÓ,T. BASTOS,A. FRIZERA-NETO

期刊论文

Towards Cr(VI)-free anodization of aluminum alloys for aerospace adhesive bonding applications: A review

Shoshan T. Abrahami, John M. M. de Kok, Herman Terryn, Johannes M. C. Mol

期刊论文

Community dynamics of ammonia oxidizing bacteria in a full-scale wastewater treatment system with nitrification stability

Xiaohui WANG, Xianghua WEN, Hengjing YAN, Kun DING, Man HU

期刊论文